Ozone that encounters the blood during ozone applications is broken down into oxygen and oxygen radicals. The hydrogen peroxide and lipid peroxide products formed in the blood plasma activate the body's natural antioxidant enzymes. The synthesis of proteins that are effective in tissue regeneration increases and causes the stimulation of mediator products of the immune system. This event, which temporarily changes the redox balance of the plasma, is called therapeutic shock. This situation triggers the body's antioxidant and anti- inflammatory mechanisms, revealing the effect of ozone therapy.

There are thousands of ozonotherapy clinics in many countries in the world such as Germany, England, USA, Japan, Malaysia, Brazil, as well as private hospitals that only perform ozone therapy and a chair at Siena University in Italy.

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